Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma
Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway.Recent biologic insights and therapeutic targeting of Quilt Patterns MAPK-alterations have dramatically shifted the treatment approach in pLGG.While chemotherapy rem